Current Issue : October - December Volume : 2018 Issue Number : 4 Articles : 6 Articles
Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with\nMalpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC\nusually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive\nforms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes.\nTreatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic choice depends on several\nfactors, such as anatomic location, risk factors for tumor recurrence, age, and health status of the patient. This reviewaims toprovide\nan overview of the current evidence on therapeutic surgical and nonsurgical management of invasive cSCC....
Aim.To clarify the association between the single nucleotide polymorphisms (SNPs) in the NLRP1 and NLRP3 and PsoriasisVulgaris\n(PsV) in the ChineseHan population. Methods.We genotyped eight SNPs, four fromNLRP1 (rs8079034, rs11651270, rs11657747, and\nrs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls\nin the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and\nhaplotype frequencies were analyzed using a case-control study design. Results.We identified two SNPs, rs3806265 and rs10754557,\nin NLRP3 that were significantly associated with PsV.The genotype distribution of the rs3806265 SNP was significantly different\nbetween cases and controls (...
Purpose: Wrinkles are the most visually obvious features of aging and are\nthe prime target of a vast number of products (both medical and cosmetic).\nIt is important for clinicians to be able to grade wrinkles objectively. Although\nwrinkles are easily recognisable for humans, it remains a very challenging\ntask for computer vision systems to detect them automatically. In\nour center, we developed a wrinkle detection algorithm based on a technique\ncalled ââ?¬Å?reversible jump Markov chain Monte Carlo framework with\ndelayed rejectionââ?¬Â. This system is able to accurately and rapidly detect wrinkles.\nMethods: 300 images were submitted to the analyser for reading. Each\nimage was analysed with a million iterations in ten minutes. The same 300\nimages were sent to a dermatologist for post-analyser evaluation. The system\nwas trained to detect major and minor wrinkles. The results were\nbenchmarked against the reviewing dermatologist. Results: Out of 300 patients,\nthe pickup rate for major wrinkles was 100%. However, on average it\nwould be able to trace out only approximately 56.5% of the entire length of\nthe wrinkle. The analyser was also able to detect minor wrinkles. However,\nthe detection rate was only 13.4%. Conclusion: Our system is able to accurately\ndetect all major wrinkles. This enables physicians to track progress of\nantiwrinkling techniques such as Botox or surgical facelifts. Our system is\nalso low cost as the wrinkle detection can be simply based off simple photographs....
Pruritus, the most common cutaneous symptom, is widely seen in many skin complaints. It is an uncomfortable feeling on the skin\nand sometimes impairs patients� quality of life. At present, the specific mechanism of pruritus still remains unclear. Antihistamines,\nwhich are usually used to relieve pruritus, ineffectively work in some patients with itching. Recent evidence has suggested that,\napart from histamine, many mediators and signaling pathways are involved in the pathogenesis of pruritus. Various therapeutic\noptions for itching correspondingly have been developed. In this review, we summarize the updated pathogenesis and therapeutic\nstrategies for pruritus....
Background: Neck contracture after burns is a major complication that affects\nfunction and cosmesis. The aim of covering the raw area and defects is\nthrough using good quality pliable skin. Full thickness skin graft allows a large\ndimension sheet of good quality skin with low donor-site morbidity. Also it\nprovides similar skin quality to the recipient areas with much less cosmetic\ndifference. Methods: Four men and eight women underwent neck contracture\nrelease and reconstruction from December of 2015 to August of 2016. Mean\npatient age was 29 years (range from 12 to 46 years). Burn scar contracture\nreleases were performed and cervicoplasty was added for optimal neck appearance.\nUniformly full thickness skin grafts were applied. Both lateral ends\nof these grafts (release incisions) were designed with a fishtail shape for sufficient\nrelease and to minimize linear scar band formation in the most lateral\nregion of the neck. Results: Full thickness skin grafts as large as 24 �± 12 cm\n(in length) and 10 - 15 cm (in width) were used. All grafts were taken without\nsignificant complications. Range of neck motion increased, and the cervico-\nmental angle was regained in all patients. A highly natural neck contour\nwas universally obtained without a secondary debulking procedure. Conclusions:\nFull thickness skin grafts for treatment of post burn neck contraction\ngive good functional and cosmetic results. They give similar color match and\ngood skin quality, also help in regaining of cervico-mental angle....
There are many situations where the skin and underlying soft tissues are compromised\nby mechanical loading in the form or pressure, or pressure in combination\nwith shear. If sustained, this can lead to damage in the tissues particularly adjacent to\nbony prominences, resulting in chronic wounds. An array of bioengineering technologies\nhave been adopted to assess the integrity of loaded soft tissues. This paper aims\nto review these approaches for the quantification, simulation and early detection of\nmechanically-induced skin damage. The review considers different measurements at\nthe interface between the skin and support surface/medical device, involving pressure,\nshear, friction and the local microclimate. The potential of the techniques to monitor\nthe physiological response of the skin to these external stimuli including biophysical\nmeasurement devices and sampling of biofluids are critically analysed. In addition, it\nincludes an analysis of medical imaging technologies and computational modelling\nto provide a means by which tissue deformation can be quantified and thresholds for\ntissue damage defined. Bioengineering measurement and imaging technologies have\nprovided an insight into the temporal status of loaded skin. Despite the advances in\ntechnology, to date, the translation to clinical tools which are robust and cost effective\nhas been limited. There is a need to adapt existing technologies and simulation\nplatforms to enable patients, carers and clinicians to employ appropriate intervention\nstrategies to minimise soft tissue damage....
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